Terug

Postdoctoral Researcher in Tumor-Microbiome Research

You have 10 more days to apply
Are you looking for a challenging research project within a leading academic medical center? And are you excited about contributing to an improved understanding of how microbiota impact human health and disease? Then we would like to meet you! While many human disorders, including tumor diseases, have been associated with changes in the gut microbiome, it is less clear which microbes can invade tumor tissues and which tumor subtypes exhibit characteristic tissue microbial signatures. Moreover, while there is early evidence for microbes colonizing certain tumors, many questions remain about how microbes colocalize and interact with specific host cell populations at the molecular level.

Share this page
Share this page through LinkedIn
Share this page through Twitter
Share this page through Facebook
Share this page through email
Share this page through WhatsApp

About your role

In this project, you will spatially map microbes in tumor tissues and analyze molecular microbe-host crosstalk by generating and integrating spatial and bulk omics data across various modalities. You will work together with other members of our interdisciplinary team as well as with external collaborators from the LUMC and beyond that share our interest in spatial omics (

Leiden, NL:
Noel de Miranda;

Heidelberg, DE:
Jan Korbel, Mathias Heikenwaelder, Julio Saez Rodriguez, Jens Puschhof, Eran Elinav;

Stockholm, SE:
Stefania Giacomello, Eduardo Villablanca).

About you

• You hold a PhD degree in any biomedical discipline.
• Excitement for high-throughput approaches and quantitative analysis.
• A keen interest in embarking on ambitious research projects to gain a better understanding of the role of microbes in tumor development and patient outcome.
• Demonstrated experience in one of the following areas:
• Fluorescence microscopy / spatial omics technologies: Experience in fluorescence microscopy, knowledge of modern spatial technologies (including various multiplex FISH approaches), and practical experience in microbiology and/or cell culture. Ideally, experience with automated image acquisition, designing/using microfluidics devices, and/or other lab automation and high-throughput methods. Interest in applying these techniques to characterize bacterial virulence, adhesion, and invasion mechanisms relevant to cancer.
• Bioimage and spatial data analysis: Theoretical knowledge and practical computational skills (preferably using Python) in quantitative bioimage or spatial omics analysis, including image segmentation, object/spot recognition, and designing/decoding fluorescence barcodes. Looking forward to utilizing these skills for the integrative analysis of new data modalities capturing microbial and host features, aiming to gain insights into molecular host-microbe interactions.
• Biostatistics and machine learning applications in microbiome research: Thorough understanding and practical experience in analyzing sequencing or other omics data using statistical and machine learning methods (ideally including metagenomics or other microbiome data). Eagerness to apply such approaches in challenging microbiome projects to understand how microbes interact with the host and how microbial influences affect tumor progression and treatment outcomes.

Our offer

Getting better by breaking new ground; that's our mission. This applies not only to healthcare, but also to our employees. In order to be able to continue to learn and develop, we offer internal and external training. You are also entitled to an end-of-year bonus (8,3%), holiday allowance, sports budget and bicycle scheme. Furthermore, as an employee of LUMC, you are also affiliated with the ABP pension fund. This means that 70% of your pension premium is paid by LUMC, leaving you with a higher net salary. Nice, right?

About your workplace

The LUMC, situated in Leiden, the Netherlands, is an academic medical center for patient care, research and education, aiming to meet the challenges of tomorrow’s health care. It has a strong focus on research, connecting and combining fundamental research into disease-causing mechanisms with patient-focused studies in areas like oncology, regenerative medicine and population health. The LUMC has research facilities that include capabilities for multiple appliances. The combination with clinical and societal outreach programs allows for ground-breaking research and innovation in basic and applied science.

You will join a department where researchers from microbiology, parasitology, immunology, and infectious disease work together across disciplines on both fundamental and translational projects. You will establish local collaborations beyond LUCID with many clinical LUMC departments, including pathology, oncology, and gastroenterology, as well as with bioinformaticians, data scientists, and microbiologists from LUMC, LU (IBL), and Delft University of Technology.

What do we represent?

Our health is our greatest asset. Unlike any other profession, in healthcare, you can fully appreciate the entire spectrum of humanity in all its breadth. LUMC, as an academic medical center, wholeheartedly embraces that diversity! We strive for the highest quality in healthcare, education, and (international) research. We aim to be a creative and inspiring workplace. It is essential that everyone feels at home, safe, and recognized. That is why the LUMC was the first academic medical center to partner with

. Our active network, LUMC Pride, is dedicated to optimal inclusivity and diversity within our organization. Regardless of origin, gender, appearance, age, identity, orientation, or faith, you are a valuable part of our organization. Together, we are LUMC.

More information

• As a postdoctoral researcher your salary will at minimum be € 3,493 and € 5,504 at most (scale 10, CLA UMC). These figures are based on full-time employment.
• The duration of the project is four years.
• Applications from employment/recruitment agencies will not be considered.

meer...

Terug - Opslaan en terug Naar vacature

Meer vacatures van Lumc

Postdoctoral Researcher Political Ecology at KITLV

What you will be doing This research project puts the role of grassroots institutions, local communities, and local actors central in climate governance. As actors and institutions (re)shape their adaptation strategies, they
15 dagen geleden- Volledige vacature bekijken

Postdoctoral Researcher within the project Museum Lab

Key responsibilitiesYou will conduct historic and/or collections-based research on a museum history topic of your choice;You will publish an article in a peer-reviewed publication on some aspect of your research;You will
2 dagen geleden- Volledige vacature bekijken

Postdoctoral researcher in Supramolecular Chemistry

The Faculty of Science Leiden and Leiden Institute of Chemistry are looking for apostdoctoral researcher in Supramolecular Chemistry Work and profileApplications are invited for a postdoctoral position in the group of Dr.
15 dagen geleden- Volledige vacature bekijken

Postdoctoral Researcher within the project Museum Lab

The Leiden University Centre for the Arts in Society (LUCAS) invites applications for a Postdoctoral Researcher within the project “Museum Lab” (1.0 fte from 1st of August 2024 to 31st of October, 2025) The Postdoc will
4 dagen geleden- Volledige vacature bekijken